Released on: August 19, 2008, 1:43 am

Press Release Author: The Scott Partnership

Industry:

Press Release Summary: San Jose, Calif. (August 18, 2008) - Thermo Fisher Scientific
Inc. (NYSE:
TMO), the world leader in serving science, will introduce a new proteomics workflow
solution at HUPO 2008, plus major upgrades to two premier Thermo Scientific software
packages. Complementing the recent launch of the Proteome Discoverer software
platform, which provides a comprehensive and expandable platform for quantitative
and qualitative proteomics data, these latest additions provide further enhancements
of the Thermo Scientific Proteome Dynamics offering.

Press Release Body: FOR IMMEDIATE RELEASE
Mass Spectrometry
Media Contact Information:
Name: Laura Browne/Charlotte Culley
Phone: +44 1477 539539
Email: thermo@scottpr.com
Website: www.scottpr.com

Secondary Contact Information:
Stephanie Kubina
+1 (408) 965-6022
stephanie.kubina@thermofisher.com

Thermo Fisher Scientific Bolsters Proteome Dynamics Offering with HUPO Product Launches

San Jose, Calif. (August 18, 2008) - Thermo Fisher Scientific Inc. (NYSE:
TMO), the world leader in serving science, will introduce a new proteomics workflow
solution at HUPO 2008, plus major upgrades to two premier Thermo Scientific software
packages. Complementing the recent launch of the Proteome Discoverer software
platform, which provides a comprehensive and expandable platform for quantitative
and qualitative proteomics data, these latest additions provide further enhancements
of the Thermo Scientific Proteome Dynamics offering.

Proteome Dynamics is an integrated portfolio of proteomics solutions, including
reagents, sample preparation kits and protocols, mass spectrometers and
application-specific bio-software designed to work together to facilitate the
identification, quantitation and characterization of proteins. The new introductions
include:

. Automated Phosphopeptide Workflow - a complete, protocol for the automated
analysis of phosphopeptides

. SIEVE 1.2 - a major upgrade to the label-free differential analysis software used
to measure and identify changes in proteins and peptides based on the comparison of
LC/MS datasets

. ProSightPC 2.0 - which extends the capabilities of the industry-leading top-down
identification software to now support the identification and characterization of
proteins from all high mass accuracy tandem mass spectrometry experiments.

Over the past decade, the field of proteomics has progressed to the point that it
has a significant impact on cutting edge developments in biology and medicine.
Thermo Fisher has been moving science forward with the development of powerful
proteomics research that breaks the boundaries of traditional qualitative proteomic
analyses to advance quantitative proteomics, thereby creating a dynamic picture of
proteomes.

The new Automated Phosphopeptide Workflow combines the power of Thermo Scientific
technologies with the Pierce Phosphopeptide Enrichment Kit, the Kingfisher Flex
magnetic bead purification system and the LTQ Orbitrap XL ETD hybrid mass
spectrometer to enable fully automated analysis of phosphopeptides. Scientists
involved in mapping signalling pathways have found that phosphopeptide enrichment by
immobilized metal and metal oxide affinity chromatography followed by MS analysis is
a powerful technique.
However, the complexity of the samples and low-throughput handling procedures have
proved a major handicap. The new Thermo Scientific integrated protocol provides a
simple, robust solution to these problems.
\"The output from each step in the sample preparation and analysis process is
optimized,\" explains Andreas Huhmer, director of proteomics marketing at Thermo
Fisher Scientific. \"The workflow enables scientists to move seamlessly through the
whole protocol.\"

Also launching at HUPO 2008 will be Thermo Scientific\'s SIEVE 1.2 Software.
SIEVE automates the label-free differential expression of proteins and peptides by
comparing LC/MS datasets of \"healthy\" or control samples to treated or \"diseased\"
samples to determine if there are differences - all without the need for isotopic
labels. Previously, only pairs of single analyses or datasets could be compared.
However, in research areas such as biomarker discovery, being able to look at trends
in the data is essential, and SIEVE 1.2 now provides the ability to look at multiple
time points or dosing points within a single trend analysis.

\"The primary requests we received from customers after the first release of SIEVE
was the ability to monitor how their proteins were changing over time and to make it
easier to interpret the statistical results on both a peptide and protein level,\"
says Amy Zumwalt, proteomics marketing programs manager at Thermo Fisher Scientific.
\"To address this need we added the trend analysis feature for this version and also
completely re-engineered the user interface. The new wizard- driven interface makes
it easy to set up differential experiments and interpret statistical results.\"

Also being showcased for the first time will be Thermo Scientific ProSightPC 2.0
software, initially designed to facilitate top-down identification and
characterization of proteins and now enhanced to support all high mass accuracy,
high resolution MS/MS proteomics experiments.. ProSightPC 2.0 enables
high-throughput processing of all accurate mass MS2 data, whether from top-down,
middle-down or bottom-up experiments, and includes the characterization of proteins
with known PTMs. \"Thermo Scientific ProSightPC 2.0 is specifically geared towards
hybrid spectrometry techniques and also supports data generated by the new LTQ
Orbitrap XL ETD mass spectrometer,\"
says Andreas Huhmer. \"This provides researchers with a unique tool to decipher
intricate differences of protein isoforms and variants.\"

Like SIEVE, a new graphical interface has made it much easier to use. And,
importantly, it now offers automatic LC-MS file processing. Previously, peaks had to
be chosen manually before processing, but now an entire chromatogram can be chosen,
allowing all the peaks to be analyzed automatically.

For more information on Proteome Dynamics, the comprehensive Thermo Scientific
quantitative proteomics platform, please visit the booth #34 at HUPO in Amsterdam,
August 16-20 2008. Alternatively, please call +1 800-532-4752, email
analyze@thermofisher.com or visit www.thermo.com/proteomics.

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving
science.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science,
enabling our customers to make the world healthier, cleaner and safer. With annual
revenues of $10 billion, we have more than 30,000 employees and serve over 350,000
customers within pharmaceutical and biotech companies, hospitals and clinical
diagnostic labs, universities, research institutions and government agencies, as
well as environmental and industrial process control settings. Serving customers
through two premier brands, Thermo Scientific and Fisher Scientific, we help solve
analytical challenges from routine testing to complex research and discovery. Thermo
Scientific offers customers a complete range of high-end analytical instruments as
well as laboratory equipment, software, services, consumables and reagents to enable
integrated laboratory workflow solutions. Fisher Scientific provides a complete
portfolio of laboratory equipment, chemicals, supplies and services used in
healthcare, scientific research, safety and education. Together, we offer the most
convenient purchasing options to customers and continuously advance our technologies
to accelerate the pace of scientific discovery, enhance value for customers and fuel
growth for shareholders and employees alike. Visit www.thermofisher.com.

For further press information please contact: Laura Browne, The Scott Partnership, 1
Whiteside, Station Road, Holmes Chapel, Cheshire. CW4 8AA United Kingdom Tel: + 44
1477 539539 Fax: +44 1477 539540 E-mail:
thermo@scottpr.com

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Contact Details: Media Contact Information:
Name: Laura Browne/Charlotte Culley
Phone: +44 1477 539539
Email: thermo@scottpr.com
Website: www.scottpr.com

Secondary Contact Information:
Stephanie Kubina
+1 (408) 965-6022
stephanie.kubina@thermofisher.com